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Chemistry of ageing

Edited by: Elizabeth Ostler

Collection published: 17 March 2012

Last updated: 25 April 2012

Gerontology has traditionally been dominated by biological research groups. In recent years, the potential impact of chemical analysis and small molecule interventions has become widely recognised, and there are now a growing number of chemists undertaking ageing research. Research into ageing spans the full range chemistry. Advanced analytical and physical techniques are being used to observe age-related changes in living organisms. Equally, novel synthetic and medicinal chemistry is generating small molecule tools for the dissection of complex biological pathways, as well as potential life- and health-span extending therapeutics.

This thematic issue on the chemistry of ageing covers topics such as: glycation, oxidative stress and other degenerative processes; cellular senescence, mechanistic dissection and interventions; telomerase inhibitors and activators; small molecules with life-extending activity such as resveratrol and rapamycin; and novel methods for mining complex cohort and life-course data.

		Review Chemical consequences of cutaneous photoageing Sarah A Thurstan, Neil K Gibbs, Abigail K Langton, Christopher EM Griffiths, Rachel EB Watson, Michael J Sherratt Chemistry Central Journal 2012, 6:34 (25 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary UV radiation exacerbates the intrinsic ageing of human skin, accelerating the onset of age-related changes, such as wrinkle formation. This review discusses experimental evidence for UV-mediated differential degradation of normally long lived dermal proteins
		Research article Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives Hasnah Osman, Afsheen Arshad, Chan K Lam, Mark C Bagley Chemistry Central Journal 2012, 6:32 (17 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary \| Graphical abstract A series of coumarin derivatives with promising antioxidant properties was synthesised using a microwave-assisted method, with several of the compounds displaying significant radical scavenging activity
		Research article Chromatographic analysis of age-related changes in mucosal serotonin transmission in the murine distal ileum Leena Parmar, Sara Fidalgo, Mark S Yeoman, Bhavik ANIL Patel Chemistry Central Journal 2012, 6:31 (11 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary \| Graphical abstract Alterations in motility and absorption in the upper bowel occur as part of the normal ageing process. Serotonin is known to influence motility, and this articleprovides new insight into alterations in the neurotransmission of serotonin during ageing
		Research article Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells Simon Larsen, Moustapha Kassem, Suresh IS Rattan Chemistry Central Journal 2012, 6:18 (17 March 2012) Abstract \| Full text \| PDF \| PubMed
		Preliminary communication Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors Terence Davis, Matthew C Dix, Michal J Rokicki, Amy JC Brook, Caroline S Widdowson, David Kipling, Mark C Bagley Chemistry Central Journal 2011, 5:83 (8 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary \| Graphical abstract Two diaminopyridine-based JNK inhibitors were synthesised and their effects on the proliferation and morphology of Werner syndrome fibroblasts were tested, and compared to a widely used JNK inhibitor

		Review Chemical consequences of cutaneous photoageing Sarah A Thurstan, Neil K Gibbs, Abigail K Langton, Christopher EM Griffiths, Rachel EB Watson, Michael J Sherratt Chemistry Central Journal 2012, 6:34 (25 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary UV radiation exacerbates the intrinsic ageing of human skin, accelerating the onset of age-related changes, such as wrinkle formation. This review discusses experimental evidence for UV-mediated differential degradation of normally long lived dermal proteins
		Research article Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives Hasnah Osman, Afsheen Arshad, Chan K Lam, Mark C Bagley Chemistry Central Journal 2012, 6:32 (17 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary \| Graphical abstract A series of coumarin derivatives with promising antioxidant properties was synthesised using a microwave-assisted method, with several of the compounds displaying significant radical scavenging activity
		Research article Chromatographic analysis of age-related changes in mucosal serotonin transmission in the murine distal ileum Leena Parmar, Sara Fidalgo, Mark S Yeoman, Bhavik ANIL Patel Chemistry Central Journal 2012, 6:31 (11 April 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary \| Graphical abstract Alterations in motility and absorption in the upper bowel occur as part of the normal ageing process. Serotonin is known to influence motility, and this articleprovides new insight into alterations in the neurotransmission of serotonin during ageing
		Research article Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells Simon Larsen, Moustapha Kassem, Suresh IS Rattan Chemistry Central Journal 2012, 6:18 (17 March 2012) Abstract \| Full text \| PDF \| PubMed
		Preliminary communication Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors Terence Davis, Matthew C Dix, Michal J Rokicki, Amy JC Brook, Caroline S Widdowson, David Kipling, Mark C Bagley Chemistry Central Journal 2011, 5:83 (8 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary \| Graphical abstract Two diaminopyridine-based JNK inhibitors were synthesised and their effects on the proliferation and morphology of Werner syndrome fibroblasts were tested, and compared to a widely used JNK inhibitor