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Open Access Highly Accessed Open Badges Research article

Metabolic fingerprinting of Angelica sinensis during growth using UPLC-TOFMS and chemometrics data analysis

Yiyun Qian1, Yali Wang1*, Rina Sa1, Hui Yan2, Xinbo Pan1, Yingwen Yang1 and Yujing Sun1

Author Affiliations

1 Key Laboratory of Dunhuang Medicine and Transformation, Ministry of Education, Research Institute of Angelica sinensis, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

2 Jiangsu Key Laboratory for High Technology of TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, China

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Chemistry Central Journal 2013, 7:42  doi:10.1186/1752-153X-7-42

Published: 1 March 2013



The radix of Angelica sinensis is widely used as a medicinal herbal and metabolomics research of this plant during growth is necessary.


Principal component analysis of the UPLC-QTOFMS data showed that these 27 samples could be separated into 4 different groups. The chemical markers accounting for these separations were identified from the PCA loadings plot. These markers were further verified by accurate mass tandem mass and retention times of available reference standards. The study has shown that accumulation of secondary metabolites of Angelica sinensis is closely related to the growth periods.


The UPLC-QTOFMS based metabolomics approach has great potential for analysis of the alterations of secondary metabolites of Angelica sinensis during growth.

Angelica sinensis; UPLC-QTOFMS; Metabolomics; Principal component analysis (PCA); Chemometrics