Open Access Research article

Synthesis and preliminary in vivo evaluations of polyurethane microstructures for transdermal drug delivery

Florin Borcan1, Codruta M Soica1*, Srinivas Ganta2, Mansoor M Amiji2, Cristina A Dehelean1 and Melania F Munteanu3

Author Affiliations

1 Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2nd E. Murgu Sq., Timisoara, 300041, Romania

2 Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Ave., Boston, Massachusetts, USA

3 Department of Clinical Laboratory and Sanitary Chemistry, “Vasile Goldis” University, 1 Feleacului Str., Arad, 310396, Romania

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Chemistry Central Journal 2012, 6:87  doi:10.1186/1752-153X-6-87

Published: 14 August 2012

Abstract

Background

Polymers have been considered as important materials in fabrication of microstructures for various medical purposes including drug delivery. This study evaluates polyurethane as material for hollow microstructures preparation.

Results

Polyurethane microstructures were obtained by interfacial polyaddition combined with spontaneous emulsification and present slightly acid pH values. Scanning electron microscopy revealed the existence of irregular shapes and agglomerated microstructures. The material is heat resistant up to 280°C. Good results were recorded on murine skin tests in case of polyurethane microstructures based on isophorone diisocyanate. Mesenchymal stem cells viability presents good results for the same sample after 48 hours based on the Alamar Blue test.

Conclusions

The research revealed the reduced noxiousness of this type of microstructures and consequently the possibility of their use for therapeutic purposes.

Keywords:
Polyurethane; Hollow microstructures; Lysine diisocyanate ester; Drug delivery; Zeta potential; CD1Nu/Nu mice; Noxiousness

Graphical abstract