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Experimental determination of the oral bioavailability and bioaccessibility of lead particles

Elise Deshommes1, Robert Tardif2, Marc Edwards3, Sébastien Sauvé4* and Michèle Prévost1

Author Affiliations

1 Civil, Geological, and Mining Engineering Department, NSERC Industrial Chair on Drinking Water, Ecole Polytechnique de Montréal, CP 6079, Succ. Centre-Ville, Montréal, QC, H3C 3A7, Canada

2 Environmental Health and Occupational Health Department, ESPUM (École de Santé Publique de l’Université de Montréal), C.P. 6128, succ. Centre-ville, Montréal, QC, H3C 3J7, Canada

3 Department of Civil and Environmental Engineering, Virginia Tech University, 418 Durham Hall, Blacksburg, VA, 24061, USA

4 Department of Chemistry, Université de Montréal, 2900, Édouard-Montpetit, Montréal, QC H3C 3A7, Canada

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Chemistry Central Journal 2012, 6:138  doi:10.1186/1752-153X-6-138

Published: 22 November 2012


In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.

Oral bioavailability; Bioaccessibility; Lead [Pb] particles; In vivo tests; In vitro tests